Flexuron®: A Revolutionary Step Forward in Joint Comfort

Rolling over to get out of bed… Wrapping your hand around a door knob… Taking the dog for a walk… Riding your bike… Gardening… Getting down on the floor to play with the kids…

For millions of people, these are everyday activities that they do without much thought—and without having to deal with joint health. But for millions of other people, they are a struggle—a chore because their joints aren’t as young as they used to be. And if you are one of the many adults who report joint health issues in national surveys then you know what it is like to skip something you enjoy because your joints made you put on the brakes.1
There are many reasons why a person could be having trouble with their joints but aging and injury are the most prevalent. And while we can do our best to avoid injury and still end up getting injured anyway, there is no known way to avoid aging. However, there are some things you can do for your joints that can help mitigate the effects of normal aging or make dealing with the after-effects of an injury a bit easier: see your doctor, rest, exercise, lose weight, use heat or cold, and take Flexuron®, a new nutritional supplement that out-performed glucosamine-chondroitin for promoting optimal joint comfort in clinical trials.*†

6 Tips for Taking Care of Your Joints

1. See Your Doctor: Your doctor should always be the point-person for your joint health care. Injuries should be attended to as soon as possible. And your doctor can help guide you through a healthy aging routine tailored to your specific needs.

2. Rest: Sounds simple, right? But let’s face it, getting proper rest can be difficult in today’s fast-paced, demanding world. But your joints need proper rest every day if they are to avoid being over-taxed.

3. Exercise: Counter-intuitive, but just as important as getting proper rest for your joints. Joints are a “use-it-or-lose-it” part of your body, as reported by a study in the Annals of the Rheumatic Diseases, which observed that if you don’t use your joints, the cartilage covering them tends to get thinner.2 And a second study published in the journal Arthritis and Rheumatism showed that moderate exercise can increase the thickness of joint cartilage and improve joint performance.3 So use your joints—but use them properly (which is where Tip #1 – See Your Doctor – comes into play again).

4. Lose Weight: Weight can be a sensitive topic, but your joints are sensitive to weight. Multiple studies have shown the relationship between body weight and joint discomfort, with one reporting that “being only 10 pounds overweight increases the force on the knee by 30-60 pounds with each step.”4

5. Use Heat… Or Cold: It can be confusing whether to use heat or cold on your joints. Sometimes the answer is one or the other, and sometimes the answer is both (though not at the same time).

Heat is good for soothing stiff joints because it enhances circulation and delivers nutrients to the joints and surrounding muscles. 5 Some people prefer heating pads while others like using moist heat packs. Whichever you use, follow the instructions on the device and do not use it for more than 20-minutes at a time.

Cold, on the other hand, is used for reducing swelling and inflammation because it restricts blood flow to the area and numbs the nerve endings. However, whether you use a frozen bag of peas or an ice pack, do not apply cold for more than 20-minutes.5

6. Use Flexuron®: Getting proper nutrition to your joints can be key to improving their comfort, flexibility, and mobility. Flexuron® is a patented combination of three key nutrients for joint health: omega-3 from krill oil, antioxidant-rich astaxanthin, and hyaluronic acid, which is a component of your joint’s lubricating synovial fluid.*

When people in the past thought about joint comfort supplements, glucosamine-chondroitin is what most readily came to mind. However, Flexuron® will change that. In a double-blind, placebo-controlled clinical study, the Flexuron® formula performed on average 3-to-5-times better that glucosamine-chondroitin as reported by test subjects using the WOMAC Pain Score Scale (The Western Ontario and McMaster Universities Arthritis Index, a widely used set of protocols for assessing pain).† Study participants reported improved joint comfort in as little as 7 days, with increasing improvement over the course of 56 days when measured on the VAS Scale (the Visual Analog Scale, which measures subjective attitudes).

It’s the special combination of ingredients in Flexuron® that make the difference:

PhosphoBoost™ Krill Oil is a great source of Omega-3, and the phospholipids version used in Flexuron® carries the EPA & DHA components of Omega-3 directly into your cells, promoting absorption.* A meta-analysis of studies on Omega-3 concluded that supplementation can improve joint comfort.6

The molecular structure of Astaxanthin gives it an exceptional ability as an antioxidant to help fight joint damage caused by free radical oxidative stress.* Astaxanthin is also valued for a number of other stellar benefits including muscle endurance and circulation, both of which can play a role in joint health.*

Low Molecular Weight Hyaluronic Acid serves as a building block for healthy joints and skin.* This gel-like substance is the joint matrix’s “shock absorber,” making it a key component of joint health and comfort.* Unfortunately, the body’s own hyaluronic acid level begins to decline as we age. Supplementing with Flexuron® can help replace some of what the body has lost.*

Put It All Together For Healthy Joints

Your joints support you, so it’s only natural that you will want to support them. Achy joints are never fun; they can slow you down and even keep you from doing the things you enjoy. But with proper care — doctor visits, rest, exercise, weight loss, heat/cold, and Flexuron® — you can increase your joint comfort and flexibility and improve your mobility.* Try something new today to give your joints a helping hand and your joints will give you a standing ovation!

1 – https://www.webmd.com/pain-management/guide/joint-pain#1. Accessed June 2018.

2 – Eckstein F, Lemberger B, Gratzke C, Hudelmaier M, Glaser C, Englmeier KH, Reiser M. In vivo cartilage deformation after different types of activity and its dependence on physical training status. Ann Rheum Dis 2005;64:291-295.

3 – Roos EM, Dahlberg L. Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: A four-month, randomized, controlled trial in patients at risk of osteoarthritis. Arthritis Rheum 2005;52:3507-3514.

4 – Role of Body Weight in Osteoarthritis. https://www.hopkinsarthritis.org/patient-corner/disease-management/role-of-body-weight-in-osteoarthritis/. Accessed June 2018.

5 – Using Heat and Cold for Pain Relief. https://www.arthritis.org/living-with-arthritis/treatments/natural/other-therapies/heat-cold-pain-relief.php. Accessed June 2018.

6 – A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. RJ Goldberg and J Katz. https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0024571/. Accessed June 2018.

† – 3 to 5 Times Better than Glucosamine and Chondroitin at Promoting Total and Maximum Joint Comfort as measured in Clinical study (improvement in WOMAC Pain Scores after subtracting out the placebo response).

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Hyaluronic Acid and Vision

Hyaluronic acid is synthesized within the human eye and is secreted into both tears and the aqueous humor of the eye in its non-acidic form, hyaluronidate. On the ocular surface, tears with normal hyaluronidate content exhibit greater lubrication during blinks. Yet while the eyelid is still, hyaluronidate maximizes the thickness of the protective fluid covering the surface of the eye – another reflection of the special properties of hyaluronidate. Within the eye itself, hyaluronidate forms part of a web of large molecules that confer structural stability to the retina and help keep it attached to the underlying cell layers.

Both advancing age and dry eyes reduce tear production and the amount of hyaluronidate that is secreted in tears; complaints about burning, itching, a sensation of the presence of a foreign body, redness and heaviness of the eyelids are common. Hyaluronic acid replacement, via drop form, can promote normal eye functions, as shown by the results of a study published in the British Journal of Ophthalmology, which assessed the effects of eye drops containing hyaluronic acid.5

Research consistently demonstrates that the insertion into the eyes of drops containing sodium hyaluronidate several times daily decreases burning, dryness, “foreign body” sensation, itching and mucous discharge. At the same time, tear formation is increased. These tears help protect the cornea from environmental insults, indicating that hyaluronic acid acts both on the surface of the eye and within the eye. The chemical process of vision produces a number of oxidizing by-products.6 The gradual steady accumulation of oxidative damage interferes with the functions of all parts of the eye. The hyaluronic acid in tears acts as a powerful antioxidant that preserves the structure and function of the visual apparatus.7

5. Aragona P, Papa V, Micali A, Santocono M, Milazzo G. Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye. Br J Ophthalmol 2002;86:181-184.
6. Rotstein NP, Politi LE, German OL, Girotti R. Protective effect of docosahexaenoic acid on oxidative stress-induced apoptosis of retina photoreceptors. Invest Ophthalmol Vis Sci 2003;44:2252-2259.
7. Debbasch C, De La Salle SB, Brignole F, Rat P, Warnet JM, Baudouin C. Cytoprotective effects of hyaluronic acid and Carbomer 934P in ocular surface epithelial cells. Invest Ophthalmol Vis Sci 2002;43:3409- 3415.

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How Does Oral Hyaluronic Acid Work?

Traditionally, hyaluronic acid has been used as an injectable to promote joint health and support joint structure. There have also been questions regarding the absorbability of hyaluronic acid when taken orally. Research shows that oral hyaluronic acid is in fact absorbed and that it functions in at least three important ways. Hyaluronic acid is a large molecule with repeating subunits that, when taken orally, naturally goes through the process of digestion in the digestive tract. Studies show that 1) A portion of the hyaluronic acid is absorbed intact, 2) A portion of it is broken down into its component sugars and absorbed in this way (providing building blocks the body can use to remanufacture hyaluronic acid, and 3) Hyaluronic Acid acts to stimulate the growth of beneficial bacteria in the digestive tract, which promote immune system health and lead to overall health of the joints, skin and connective tissue throughout the body. These three unique and distinctly separate mechanisms of activity illustrate the ability of oral hyaluronic acid to benefit and support the body’s connective tissue.

To reaffirm the efficacy of oral hyaluronic acid for joint support, let’s look at the results of an important Japanese study. This study, which was published in 2008, was carried out to assess the efficacy of oral hyaluronic acid in promoting healthy joint function and mobility. Fifteen individuals with achy knees were supplemented with 240 mg of highly purified hyaluronic acid daily for twelve weeks. Positive results were evident after 4 weeks of supplementation as the individuals had significant improvements in knee joint function and comfort. The benefits continued throughout the duration of the study, showing that oral hyaluronic acid supplements are effective for promoting healthy joint function.11

Now that we know that studies affirm the effectiveness of oral hyaluronic acid, let’s look at evidence supporting the three mechanisms of activity. Bioavailability studies in animals show that hyaluronic acid taken orally reaches joint tissue. Radioactively-labeled particles of hyaluronic acid were found to reach the skin, bone and joints of rats after oral administration, showing that a percentage of orally administered hyaluronic acid is absorbed intact.12 A further percentage of hyaluronic acid taken as supplements is digested and broken down into its component molecules. These components are absorbed into the bloodstream, providing the body with the building blocks necessary to produce hyaluronic acid on its own, allowing it to replenish its own stores. Finally, a very interesting study was carried out in which rats were administered hyaluronic acid orally. Researchers found that the orally administered nutrient was fermented by gut bacteria as a source of nutrition. Hyaluronic acid was shown to act as a prebiotic, as it increased the level of Lactobacillus and Bifidobacterium species in the intestinal tract.13 Taking these important studies into account, we can see that oral hyaluronic acid supplements have both direct and indirect effects in supporting the health of our joints, skin and connective tissue. Given its broad range of potential benefits, hyaluronic acid is a crucial and important nutrient for healthy aging.

11. Sato T, Iwaso H. An Effectiveness Study of Hyaluronic Acid (Hyabest® (J)) in the Treatment of Osteoarthritis of the Knee. J New Rem & Clin 2008;57(2):128-137.
12. Balogh L, Polyak A, Mathe D, Kiraly R, Thuroczy J, Terez M, Janoki G, Ting Y, Bucci LR, Schauss AG. Absorption, uptake and tissue affinity of high-molecular-weight hyaluronan after oral administration in rats and dogs. J Agric Food Chem 2008 Nov 26;56(22):10582-93.
13. Ishibashi G, Yamagata T, Rikitake S, Takiguchi Y. Digestion and Fermentation of Hyaluronic Acid. Journal for the Integrated Study of Dietary Habits 2002; 13(2): 107-111.

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Joint Health – Hyaluronic Acid

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each week, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Joint Health – Hyaluronic Acid

Hyaluronic acid is a component found in normal, healthy joint tissue. As shown in research recently published in the Journal of Physiology, hyaluronic acid is responsible for keeping the joints hydrated – a property vital to the ability of joints to absorb shock and carry weight.1 The slowdown in hyaluronic acid replenishment in joint cartilage that accompanies getting older can result in hyaluronic acid deficiency within a joint. Hyaluronic acid deficient joints become dry and lose their cushioning properties, predisposing them to a decrease in mobility.

Published scientific research has demonstrated that ensuring sufficient amounts of hyaluronic acid are available to your joints can promote joint health and function. The importance of the function of hyaluronic acid in joint tissue clearly substantiates the benefits of including it in your personal Joint Health program. See much more on hyaluronic acid in the dedicated chapter found later in the book.

Next Best Kept Secrets to Healthy Aging topic:
Joint Health – Fish Oils

1. Scott JE, Stockwell RA. Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid. Implications in osteoarthrosis. J Physiol 2006; Mar. 31. doi: 10.1113/ jphysiol.2006.108100 (http://jp.physoc.org/cgi/content/abstract/jphysiol.2006.108100v1).

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Joint health treatments should be exhausted

Many people with major joint health problems opt for invasive procedures after trying a handful of different therapies. This approach may bring immediate relief, but experts say that individuals should be sure to exhaust all options before considering any type of serious treatment approaches.

Hyaluronic acid supplements are on the list of things people should try before resorting to major medical interventions. Numerous studies have shown that this nutrient plays an important role in preserving joint health.

Dr. Edward Petrow, a surgeon at the Tuscon Orthopaedic Institute, told the Green Valley News and Sun that this nutrient may serve to lubricate the spaces in between bones. This may benefit a person's joint health.

He told the news sources that this approach may be significantly less invasive than other medical treatments, and it should be tried before individuals resort to other therapies.

The body naturally has a certain amount of its own hyaluronic acid, but this may be insufficient for individuals who want to support their joint health. Supplements may be able to help individuals boost their levels. 

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New study finds joint health benefits of hyaluronic acid

Hyaluronic acid may be one of the most effective approaches to preserving joint health, according to a new study from a team of Korean researchers. The findings were published in the Journal of the Korean Foot and Ankle Society.

The researchers examined the effects of administering hyaluronic acid to 27 individuals. Results indicated that these individuals showed significant support for their joint health, particularly in regards to the condition of their ankles. These joints are generally vulnerable to problems.

Hyaluronic acid has been shown in numerous studies to work to cushion joints and prevent bones from grinding against one another, which is one of the most common causes of joint pain.

The researchers said the benefits from using hyaluronic acid appeared to persist for more than a year in their study. Rates of patients who were satisfied with the treatment were as high as 88 percent. This may indicate that the substance can play a critical role in the preservation of joint health.

Many people may not be familiar with the benefits of hyaluronic acid, but those who are concerned about their joint health may benefit from looking into it.

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Fast Action H.A. Hyaluronic Acid Super Formula from Purity Products

For people who want even faster results from their joint supplement, we proudly introduce Fast Action H.A. — our most advanced hyaluronic acid  formula ever.

To learn more, visit:

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Hyaluronic acid may help to support joint health

Exercise alone will not prevent hips and knees from deteriorating. Fortunately, hyaluronic acid may help to support the joint health. Lubrication of these areas is important to maintenance, as the fluid that normally exists in this region allows for easier friction-free movement.

In England more than 120,000 joint replacement operations take place each year. The frequency of these procedures in the U.K. is rising steadily, reported The Daily Mail.

Many of these operations are a result of declining joint health, which is a problem that is often ignored until surgery becomes necessary, noted the news source.

These operations tend to be painful, and the aftermath of the surgery leaves many people affected for months, as forced immobility can affect a daily routine. Physical therapy is often a necessary course of action following these procedures, according to chief medical officer at the American Cancer Society Dr. Otis Brawley.

Along with the pain that might come from the surgeries, the cost of complicated medical procedures and the process that follows the surgery tends to be high.

Taking hyaluronic acid might help support healthy joints. 

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Hyaluronic Acid and Keeping Skin Healthy Longer

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Keeping Skin Healthy Longer with Hyaluronic Acid

Aging skin is characterized by a significant loss of elasticity coinciding with a reduced content of hyaluronic acid.8 Because hyaluronic acid is the most abundant water-binding glycosaminoglycan in healthy skin, loss of hyaluronic acid results in decreased water content and loss of elasticity. In addition, loss of hyaluronic acid is accompanied by increased compaction of collagen fibers. Skin depleted of hyaluronic acid takes on a dry and wrinkled appearance, much like joints depleted in hyaluronic acid lose their ability to retain moisture, and thus have decreased cushioning and shock-absorbing ability.

In contrast, enrichment of the dermal layer of the skin with hyaluronic acid optimizes collagen organization (“packing”). Hyaluronic acid also has been shown to promote intercellular communication, allowing cells to cooperate more efficiently in organizing the collagen they produce. Hyaluronic acid contributes to the organization and structure of the skin by increasing the amount of water that is bound into the structure of the skin – the better hydrated the skin, the more flexible it is.9 In addition, hyaluronic acid enrichment supports the ability of new skin cells to replace old, further facilitating the restoration and maintenance of healthy skin.

When the skin is exposed to oxidizing chemicals or conditions (such as sunlight), the lipid structures of cell membranes are susceptible to increased rates of oxidative peroxidation.10 Skin cells with membranes that have been oxidized shrink and deform, losing cell-to-cell contact and “leaking” increased amounts of evaporative water from the abnormal spaces between cells, causing dehydration of the skin and reducing its flexibility.10

As reported in a paper published recently in the Journal of Pharmacology and Pharmaceutical Science hyaluronic acid is a powerful antioxidant within the skin that acts to maintain skin health by preventing lipid peroxidation and by maintaining the normal level of hydration within the skin.10 These properties of hyaluronic acid promote flexible and supple skin, making hyaluronic acid a vital component of your healthy skin preservation program.

Next Best Kept Secrets to Healthy Aging topic:
How Does Oral Hyaluronic Acid Work?

8. Guinot C, Malvy DJ, Ambroisine L, Latreille J, Mauger E, Tenenhaus M, Morizot F, Lopez S, Le Fur I, Tschachler E. Relative contribution of intrinsic vs extrinsic factors to skin aging as determined by a validated skin age score. Arch Dermatol 2002;138:1454-1460.
9. Toole BP. Hyaluronan is not just a goo! J Clin Invest 2000;106:335-336.
10. Trommer H, Neubert RH. Screening for new antioxidative compounds for topical administration using skin lipid model systems. J Pharm Pharm Sci 2005;8:494-506.

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Hyaluronic Acid and Joint Mobility

This is part of our ongoing The Best Kept Secrets to Healthy Aging spotlight. Each day, we will be posting some of the great information that’s packed into our book, The Best Kept Secrets to Healthy Aging.

Today’s topic:
Hyaluronic Acid and Joint Mobility

Batches of hyaluronic acid are synthesized and assembled into long chains before being secreted by articular chondrocytes (cartilage cells) and synoviocytes (cells that live in the synovial lining of the joint capsule). Regardless of its source, hyaluronic acid can be incorporated into the load-bearing sugar/protein mats of joint cartilage.

As shown in research recently published in the Journal of Physiology the unique properties of the special sugars that make up hyaluronic acid attract water and are responsible for the cushioning properties of healthy joint cartilage.3 Because the synthesis of its component sugars slows with age, the replenishment of hyaluronic acid within a joint also slows with age, creating an inevitable imbalance in the cartilage’s replenishment/replacement cycle. As the contact surfaces of the joint cartilage become depleted of hyaluronic acid, they become chronically dehydrated and lose their vital cushioning hydrostatic properties.

A large volume of published scientific research has demonstrated that adequate availability of hyaluronic acid can promote joint health and function. These conclusions have been echoed most recently in a mathematical analysis of the body of published research, itself published in the Journal of Family Practice.4 The strength of the evidence certainly argues in favor of adding hyaluronic acid to your personal joint health program.

Next Best Kept Secrets to Healthy Aging topic:
Vision and Hyaluronic Acid

3. Scott JE, Stockwell RA. Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid. Implications in osteoarthrosis. J Physiol 2006; Mar. 31. doi: 10.1113/ jphysiol.2006.108100 (http://jp.physoc.org/cgi/content/abstract/jphysiol.2006.108100v1).
4. Modawal A, Ferrer M, Choi HK, Castle JA. Hyaluronic acid injections relieve knee pain. J Fam Pract 2005;54:758-767.

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